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Journal papers with a DOI are now to be found on their own DOI page.


 * DOI: 10.3390/nu13020411     https://pubmed.ncbi.nlm.nih.gov/33525447/

THE CLINICAL IMPORTANCE OF VITAMIN D(CHOLECALCIFEROL): A PARADIGM SHIFT WITH IMPLICATIONS FOR ALL HEALTHCARE PROVIDERS

Dr Alex Vasquez 2004 Vitamin D monograph

https://www.inflammationmastery.com/art1 https://5206f8e7-0993-46b0-b221-a76f5b848276.filesusr.com/ugd/93e00d_a23c86e5862244f4b16585c569bf840a.pdf

Based on our review of the literature, we propose that the optimal — "sufficient and safe "— range for 25(OH)D correlates with serum levels of 40–65 ng/mL (100–160 nmol/L).

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In Finland from the mid-1950s until 1964, the recommended daily intake of vitamin D for infants was 4,000–5,000 IU, a dose that was proven safe and was associated with significant protection from type 1 diabetes. More recently, in a study involving more than 10,000 infants and children, daily administration of 2,000 IU per day was safe and effective for reducing the incidence of type 1diabetes by 80%.

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Until proven otherwise, the balance of the research clearly indicates that oral supplementation in the range of 1,000 IU/day for infants, 2,000 IU/day for children, and 4,000 IU/day for adults is safe and reasonable to meet physiologic requirements, to promote optimal health,  and  to  reduce  the  risk  of  several  serious  diseases. Safety and effectiveness of supplementation are assured by periodic monitoring of serum 25(OH)D and serum calcium.

University of Copenhagen. "Vitamin D crucial to activating immune defenses." ScienceDaily. ScienceDaily, 8 March 2010. .

Vitamin D crucial to activating immune defenses Date:    March 8, 2010 Source:    University of Copenhagen

https://www.sciencedaily.com/releases/2010/03/100307215534.htm

For the research team, identifying the role of vitamin D in the activation of T cells has been a major breakthrough. "Scientists have known for a long time that vitamin D is important for calcium absorption and the vitamin has also been implicated in diseases such as cancer and multiple sclerosis, but what we didn't realize is how crucial vitamin D is for actually activating the immune system -- which we know now. "

https://www.nature.com/articles/ni.1851

http://enformtk.u-aizu.ac.jp/mailer/to_uoa/infection-measures.html

I am not alone in my opinion, which you may dismiss as quirky and unqualified. Thousands of scientists worldwide are fighting this misinformation, which is resulting in a human medical experiment on a scale we have not witnessed in our lives before.

These include Nobel prize winner Michael Levitt of Stanford University, Luc Montagnier the Nobel laureate virologist from France. These include professors from prestigious universities all around the world such as Martin Kulldorff, Jay Bhattacharya, and John Ioannidis of Stanford University, Carl Heneghan, Tom Jefferson, and Sunetra Gupta of Oxford University, and Sucharit Bhakdi and Karin Moelling from Germany.

Medical Articles by Dr. Ray

Collection of health news, health articles and useful medical information you can use in everyday life. Jul 25 2020 The Immune System Changes With Age By Ray Schilling | autoimmune disease, diet, fish oil, food, immune system, Infectious Disease, lifestyle, omega-3 fatty acids, vaccinations, Vitamins and supplements

https://www.askdrray.com/the-immune-system-changes-with-age/

Vitamin D

The immune system is very dependent on vitamin D as the immune cells all contain vitamin D receptors. People who have less than 10 ng/mL of vitamin D in the blood are vitamin D deficient. They have much higher death rates when they get infected with the Covid-19 coronavirus.

Vitamin D regulates the expression of target genes. At the center is the vitamin D receptor, which is a nuclear transcription factor. Together with the retinoic X receptor (from vitamin A) the vitamin D receptor binds small sequences of DNA. They have the name “vitamin D response elements” and are capable of initiating a cascade of molecular interactions. The result is a modulation of specific genes. Researchers identified thousands of vitamin D response elements that regulate between 100 and 1250 genes. You need enough vitamin D for your immune system

When enough vitamin D is present in the blood (more than 30 ng/mL) the immune system releases the peptides cathelicidins and defensins, which effectively destroy bacteria and viruses.

Vitamin D has mainly an inhibitory function regarding adaptive immunity. It inhibits antibody production from B cells and also dampens the effect of T cells. Researchers reported that vitamin D3 is useful in the treatment of autoimmune diseases.

I am a slow absorber of vitamin D3 as repeat blood vitamin D levels showed. I need 10,000 IU of vitamin D3 daily to get a blood level of 50-80 ng/mL (=125-200 nmol/L). This is the higher range of normal. Everybody is different. Ask your physician to check your blood level of vitamin D. Toxic vitamin D blood levels are only starting above 150 ng/mL (= 375 nmol/L).

https://www.facebook.com/deutschetelekom/posts/10159037928203555

Da leert man den Briefkasten doch gerne!📬 Diese Woche gab es ein Überraschungspaket von unserer Personalvorständin Birgit Bohle. Neben netten und motivierenden Worten gab es auch ein wenig Sonnenschein für das Homeoffice ☀️ Wir folgen ihrer Inspiration gerne – und werden das Wochenende nutzen, um an der frischen Luft etwas Sonne zu tanken! 😊 Wie sehen eure Pläne aus? Und, ganz wichtig: Bleibt alle gesund!

You like to empty the mailbox! 📬 This week there was a surprise package from our staff chairman Birgit Bohle. In addition to nice and motivating words, there was also a little sunshine for the home office ☀️ We love to follow her inspiration - and will use the weekend to soak up some sunshine in the fresh air! 😊 What are your plans? And, very importantly, stay healthy everyone!

Nice Picture

It's a pity the paper reports Diagnostic cut-offs of levels of serum Vitamin D without comment. We have known since 2012 that vitamin d3 inhibits the production of proinflammatory cytokines at 25(OH)D levels ABOVE 30ng/ml and is best able to inhibit inflammation at 50ng/ml "while significant inhibition of LPS-induced p38 phosphorylation was achieved with 30 ng/ml and higher of 25(OH)D3. Maximum inhibition was achieved with 50 ng/ml of 25(OH)D3 [a mean inhibition of 78%. from "Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368346/ Cholecalciferol enables a signalling modality and has a half-life in that form in serum for just 24 hrs. So DAILY CHOLECALCIFEROL supplementation is required and if we want OPTIMAL INHIBITION of proinflammatory cytokines so head off a cytokines storm optimally we need a good signal and those with 25(OH)D Levels 50ng/ml or above have the most cholecalciferol in serum. Hollis 2007 Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868557/ Look at figure 2 https://i.imgur.com/E8m4F1z.png In a cytokine storm the difference between have some inhibition of inflammation and having optimal inhibition of inflammation could the death. I simply don't understand why anyone should regard 30ng/ml 75nmol/l when it costs so little to have optimal inhibition and optimal natural amounts of choleclaferol in serum daily by maintaining a NATURAL 25(OH)D level of 50ng/ml 125nmol/l. We also knew back in 2007 "No toxicity was observed at levels below 200 ng/ml, and no toxicity was observed in studies reporting a daily vitamin D intake below 30,000 IU." Risk assessment for vitamin D https://academic.oup.com/ajcn/article/85/1/6/4649294...

It is a pity vitamin d researchers don't appear to have read much if any vitamin d research.

American Institute for Economic Research WHO Deletes Naturally Acquired Immunity from Its Website Jeffrey A. Tucker – December 23, 2020

Coronavirus lived on surfaces until it didn’t. Masks didn’t work until they did, then they did not. There is asymptomatic transmission, except there isn’t. Lockdowns work to control the virus except they do not. All these people are sick without symptoms until, whoops, PCR tests are wildly inaccurate because they were never intended to be diagnostic tools. Everyone is in danger of the virus except they aren’t. It spreads in schools except it doesn’t.

On it goes. Daily. It’s no wonder that so many people have stopped believing anything that “public health authorities” say. In combination with governors and other autocrats doing their bidding, they set out to take away freedom and human rights and expected us to thank them for saving our lives. At some point this year (for me it was March 12) life began feeling like a dystopian novel of your choice.

Well, now I have another piece of evidence to add to the mile-high pile of fishy mess. The World Health Organization, for reasons unknown, has suddenly changed its definition of a core conception of immunology: herd immunity. Its discovery was one of the major achievements of 20th century science, gradually emerging in the 1920s and then becoming ever more refined throughout the 20th century.

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In effect, this change at WHO ignores and even wipes out 100 years of medical advances in virology, immunology, and epidemiology. It is thoroughly unscientific – shilling for the vaccine industry in exactly the way the conspiracy theorists say that WHO has been doing since the beginning of this pandemic.

https://www.aier.org/article/who-deletes-naturally-acquired-immunity-from-its-website/ Proc R Soc Med 1965 May;58(5):295-300. THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Sir Austin Bradford Hill

PMID: 14283879 PMCID: PMC1898525 https://pubmed.ncbi.nlm.nih.gov/14283879/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1898525/pdf/procrsmed00196-0010.pdf

Already a long time ago it was clear that not everything in medicine was amenable to a Randomised Controlled Trial (RCT) or even in need of one. In some situations it is prudent to invoke Occam's razor as a means to determine if there is a causal relationship to disease from environmental conditions. :-) (KMP) The Observer Health & wellbeing Sun 10 Jan 2021 11.00 GMT Does vitamin D combat Covid? Mattha Busby

https://www.theguardian.com/lifeandstyle/2021/jan/10/does-vitamin-d-combat-covid

'''It’s cheap, widely available and might help us fend off the virus. So should we all be dosing up on the sunshine nutrient?'''

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Writing in the Lancet in August, he said: “It would seem uncontroversial to enthusiastically promote efforts to achieve reference nutrient intakes of vitamin D… There is nothing to lose from their implementation, and potentially much to gain.” Although extremely large sustained doses of vitamin D can cause toxicity, it is otherwise harmless.

Could Most COVID-19 Deaths Have Been Prevented? January 18, 2021 Mercola.com by Dr. Joseph Mercola

https://www.organicconsumers.org/news/could-most-covid-19-deaths-have-been-prevented

In recent weeks and months, there's been an upshot of studies demonstrating the benefits of vitamin D against COVID-19. The evidence is so compelling, more than 100 doctors, scientists and leading authorities have signed an open letter calling for increased use of vitamin D in the fight against COVID-19.

Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes," the letter states, adding:3 "Vitamin D modulates thousands of genes and many aspects of immune function, both innate and adaptive. The scientific evidence shows that:

•'''Higher vitamin D blood levels are associated with lower rates of SARS-CoV-2 infection. Higher D levels are associated with lower risk of a severe case (hospitalization, ICU, or death).'''

•Intervention studies (including RCTs) indicate that vitamin D can be a very effective treatment. Many papers reveal several biological mechanisms by which vitamin D influences COVID-19.

•Causal inference modelling, Hill's criteria, the intervention studies & the biological mechanisms indicate that vitamin D's influence on COVID-19 is very likely causal, not just correlation." Open letter

https://vitamind4all.org/letter.html

Vol. 2 No. 1 (2021): Epidemic NCDs / Articles ''Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19'' Stephanie Seneff and Greg Nigh

https://ijvtpr.com/index.php/IJVTPR/article/view/23 https://ijvtpr.com/index.php/IJVTPR/article/view/23/34