Kalle Pihlajasaari

About
Vitamin-D advocate, citizen researcher.

Born in (then West) Germany, lived in Australia, Finland and South Africa and now returned to Lahti, Finland.

Studied BSc Engineering (Electrical) at the University of the Witwatersrand

Also interested in the equalizing influence of a Universal Basic Income by any name.

Interested in sustainable government of the people, I lean towards Libertarian and Social Democracy but sees the future as Open Source Government where those who are passionate make improvements in the source, those who feel wronged seek the bugs that institutionalize injustice and demand their correction and those who are content to trust the system because it harbours no secrets do not have to do anything. The only way for the lay person to truly affect government is if they can understand it and see the inner workings. For government to work well it does not need to be a complicated affair, most start simple and feature creep steps in and trojans are the result of lack of oversight and closed source.

Tips for taking prophylactic Vitamin-D3
A recent summary I posted on a Vitamin-D3 advocacy group:

Tips for taking prophylactic Vitamin-D3: 1: Take Vitamin-D3 and not Vitamin-D2 unless you have no choice 2: Take your Vitamin-D3 daily rather than less often 3: Take a magnesium supplement in addition as most modern diets are deficient 4: Take the Vitamin-D3 as oil in capsules or drops with an oily meal for best absorption 5: A daily dose of 100ug (4000IU) is accepted as safe, much higher doses have been used safely in many treatments and studies for long durations 6: You can test your serum level 4 months after altering your dose, preferably in winter if you feel the need and adjust 7: A good natural target is 125nmol/l = 50ng/ml with a safe range of 100-250nmol/l = 40-100ng/ml 8: If you have never supplemented before you can take double the dose for one or two months to raise your serum levels more rapidly 9: Take all year round wherever you live, you cannot get an overdose from extra sun, still sunshine is good for you but sun-burn is NOT 10: Vitamin-D sufficiency is linked to reduced severity of CoViD-19 disease so it is prudent to be replete. References for the above tips: 1: DOI: 10.1093/ajcn/68.4.854 Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2 DOI: 10.1210/jc.2004-0360 Vitamin D2 is much less effective than vitamin D3 in humans DOI: 10.1093/ajcn/84.4.694 The case against ergocalciferol (vitamin D2) as a vitamin supplement DOI: 10.1210/jc.2008-0350 Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly DOI: 10.1210/jc.2010-2230 Vitamin D(3) is more potent than vitamin D(2) in humans DOI: 10.1111/nbu.12293 Vitamin D2 vs. vitamin D3: They are not one and the same DOI: 10.4158/EP-2018-0415 IT'S TIME TO STOP PRESCRIBING ERGOCALCIFEROL DOI: 10.1007/s11154-019-09532-w Consensus statement from 2nd International Conference on Controversies in Vitamin D 2: DOI: 10.3945/jn.110.134742 Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation DOI: 10.1210/jc.2013-2653 The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes DOI: 10.4158/EP-2018-0415 IT'S TIME TO STOP PRESCRIBING ERGOCALCIFEROL 3: DOI: 10.7556/jaoa.2018.037 Role of Magnesium in Vitamin D Activation and Function DOI: 10.1038/s41598-021-90189-4 Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease 4: This is common knowledge 5: DOI: 10.1093/ajcn/85.1.6 Risk assessment for vitamin D DOI: 10.3389/fimmu.2021.655739 Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol DOI: 10.1210/jendso/bvab048.549 Association Between Population Vitamin D Status and SARS-CoV-2 Related Serious-Critical Illness and Deaths DOI: 10.3109/03009747309097085 Effects of Large Doses of Calciferol on Patients with Rheumatoid Arthritis: A Double-Blind Clinical Trial 6: DOI: 10.1210/jendso/bvab048.549 Association Between Population Vitamin D Status and SARS-CoV-2 Related Serious-Critical Illness and Deaths 7: DOI: 10.4049/jimmunol.1102412 Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 DOI: 10.1016/j.jiph.2020.06.021 Role of vitamin D in preventing of COVID-19 infection, progression and severity DOI: 10.1210/jendso/bvab048.549 Association Between Population Vitamin D Status and SARS-CoV-2 Related Serious-Critical Illness and Deaths DOI: 10.1016/j.jsbmb.2006.12.066 Circulating Vitamin D3 and 25-hydroxyvitamin D in Humans: An Important Tool to Define Adequate Nutritional Vitamin D Status DOI: 10.1007/s00394-012-0421-6 Vitamin D status indicators in indigenous populations in East Africa 8: DOI: 10.1210/jendso/bvab048.549 Association Between Population Vitamin D Status and SARS-CoV-2 Related Serious-Critical Illness and Deaths 9: It is common knowledge that in the temperate latitudes it is impossible to synthesize Vitamin-D3 in winter. Even the UK SACN knows this. 10: DOI: 10.1038/s41598-021-90189-4 Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease DOI: 10.1210/jendso/bvab048.549 Association Between Population Vitamin D Status and SARS-CoV-2 Related Serious-Critical Illness and Deaths DOI: 10.1016/j.jiph.2020.06.021 Role of vitamin D in preventing of COVID-19 infection, progression and severity

Easy chart to estimate a default Vitamin-D3 dose
Here are two charts that will describe the weight and BMI adjusted default dose proposal I have crafted from published medical research and those who have used Vitamin-D3 in treatment, this is for healthy individuals and should work for all the values that are included. There is nothing new or revolutionary about my chart except that it does your BMI calculation for you with the aid of your height as you have provided your weight anyway. However the chart can be used in another way. If you know or believe yourself to be of normal build then you know that your default dose will fall into the middle of the yellow band. Just run across from your height or down from your weight and you will get a fair approximation. If you are of light build then move towards the bottom left and if you are heavier set move to the top right.

The two are the same chart with just the dosing units changed, one is in ug (micro gramme) which is common in Europe and the other is in IU (International Units) which is common in the USA, it varies across the rest of the globe, use the chart that has the units you are familiar with. The chart values are rounded to the nearest 25ug = 1000IU which is a reasonable dose granularity that can be seen by even steps between cells and matches the most common supplement doses on offer. As an individual the indicated dose may not be ideal for you and you may decide to increase or decrease your dose in time, for most people your final value may be just a few cells away from where you started in the end.

For some individuals this chart will not be close to their final optimal value, these are people with individual differences, genetic mutations or diseases that cause Vitamin-D3 to be absorbed, scavenged, transported, metabolised or synthesised to a lesser or greater degree than classic humans. Such individuals may need LESS to have acceptable results, the serum level may be typical or they may get by with lower serum levels. Others with Vitamin-D resistance either genetic or acquired may need substantially MORE to achieve the immune system modulation that they need, they will generally have a higher than normal serum level. Notably in the last category appear to be a majority of Multiple Sclerosis (MS) sufferers but probably not all and medically supervised supra-physiological dose protocols have provided disease remission for numerous individuals. These charts are intended to give a guide that should bring people closer to the natural range that humans have evolved to operate in. Knowing that everyone is different it is prudent to measure the blood serum level occasionally while you tune your dose. It is best to eliminate Vitamin-D2 supplementation if possible and stick with Vitamin-D3, the form you make in your skin, this caution is most important in the USA where Vitamin-D2 prescriptions are very common. Take a Magnesium supplement, there are many to choose from and most people do not get enough to compensate for western diet. If you have side effects from a supplement, stop taking the supplement, Try a different brand, read some more, get your level tested perhaps right away, find an open minded healthcare professional and discuss, medication, genetic disorders and pre-existing conditions that may affect your Vitamin-D metabolism. If all else seems in order many people get the benefit from a different brand or formulation of the supplement. Others say large changes in dosing take a few weeks to settle down but debilitating side effects should not be tolerated and are rare. Some also take more co-factors such as Vitamin-K2 and Boron, some recommend Omega-3 fatty acids, generous hydration is recommended when approaching the higher doses or reaching higher serum levels.

If you want to keep just the essence of these charts with you the formula used to calculate the dose is given below.

The default dose in ug is calculated as Weight(kg) * BMI / 8 The default dose in IU is calculated as Weight(kg) * BMI * 5



Profound quotes
A collection of profound quotes that I have collected and crafted over the years.

Achieve 25(OH)D3 > 125nmol/l (50ng/ml) with DAILY supplementation. - Kalle Pihlajasaari 2021 Easy choices, hard life. Hard choices, easy life. - Jerzy Gregorek, 2017 A targeted subsidy is a tax on everyone else. - Kalle Pihlajasaari 2021 Politics should be durable, seek a worthy plan that will last for millennia. - Kalle Pihlajasaari 2021 It is only necessary to subvert one tier of government to control a country. - Kalle Pihlajasaari 2021 Blind belief in authority is the greatest enemy of truth. - Albert Einstein 1901 Humanity has bigger problems that trying to select the best political party to control us. - Kalle Phlajasaari 2020 Never assume malice when stupidity will suffice. - Heinlein’s Razor 1941 'Political Correctness' is not the same as 'Correctness'. It is usually a political tool used to oppress a dissenting group when expressing a logical argument is too hard. - Kalle Phlajasaari 2020 The only crime worse than regional exploitation of finite resources is transnational exploitation of finite resources. - Kalle Phlajasaari 2020 It turns out witnessing an act of human generosity releases oxytocin. - Simon Sinek 2013 Who'd have thunk it. - Frances Cora Perce 1895 I think that inherently, human beings are meaning seeking creatures. - Rutger Beregman 2020 A perfect political system must find a way to allow for the maximum of personal expression by dissidents, present day democracy is just dictatorship by the shepherded majority and can never achieve peace. - Kalle Pihlajasaari 2020 Herd resistance is cheaper than herd immunity. - Kalle Pihlajasaari 2020 There is no moral justification to be found in promoting population growth while a single person is hungry. - Kalle Pihlajasaari 2020 Just that you do the right thing. The rest doesn’t matter. Remember that very little is needed to make a happy life. The happiness of your life depends upon the quality of your thoughts. If it is not right do not do it; if it is not true do not say it. Do every act of your life as though it were the very last act of your life. Waste no more time arguing about what a good man should be. Be one. - Marcus Aurelius 180 Preparing for a collapsing global system could be even more important than trying to avoid collapse. - Graham Turner 2014 Nature is just being it's usual vacuum abhorrent self. - Marie-Louise Kellett 2020 Sane politics needs to embrace adversarial interoperability or it will stagnate and eventually be replaced. - Kalle Pihlajasaari 2019 Promoting growth in a world with finite resources must eventually lead to revolution. Politicians still proposing this as any kind of solution should be tarred and feathered. - Kalle Pihlajasaari 2018 Any faith that routinely entraps children is not very sure of its sales message and should be regarded with a large measure of circumspection. - Kalle Pihlajasaari 2017 Stuff will be automated as soon as it is statistically more profitable to automate; laws, equality, safety, morality, liability, sentiment and squeamishness will be equal victims. - Kalle Pihlajasaari 2017 Rajallinen maailma ei kestä rajatonta kasvua. - Kalle Pihlajasaari 2017 There is no moral justification to be found in promoting population growth while a single person is starving. - Kalle Pihlajasaari 2017 All constitutions that do not encourage a sustainable society are crimes against humanity. - Kalle Pihlajasaari 2017 Kaikki perustuslait, jotka ei kannusta kestävää yhteiskuntaa, ovat rikoksia ihmisyyttä vastaan. - Kalle Pihlajasaari 2017 Good fences make good neighbours. - Robert Frost 1916 (from Mending Wall) Any time someone puts a lock on something you own against your wishes, and doesn't give you the key, they're not doing it for your benefit. - Cory Doctorow 2009 But real low-hanging fruit ripens last, and should be therefore picked as late as possible. Stories are how we understand the world, and technology is how we choose our stories. Stories are propaganda, virii that slide past your critical immune system and insert themselves directly into your emotions. - Cory Doctorow 2004 Finland didn't have a damn thing but trees. Yet Finland was the finest little country in the world. - Robert A, Heinlein 1964 (Farnham's Freehold) Sadly, the easiest way to subvert any important system, with leaders, is through the leaders. - Kalle Pihlajasaari 2015 A shared sock is a lost sock. - Kalle Pihlajasaari 2015 It is difficult to get a man to understand something, when his salary depends upon his not understanding it! - Upton Sinclair 1935 (My motto and what I tell my kids so they can benefit from this life.) Remember the Creator. Do the right thing. Memento creatoris. Facere rectum. - Kalle Pihlajasaari 2013 The only stable form of government is Open Source Government. - Kalle Pihlajasaari 2013 On Facebook, always check your 'other' mailbox, there may be something there you were looking for. - Kalle Pihlajasaari 2013 We must accept that God has veto powers on our plans in life. - Kalle Pihlajasaari 2013 Unless the reformer can invent something which substitutes attractive virtues for attractive vices, he will fail. - Walter Lippmann 1913 I can see a day the world will look upon feeding animal flesh to children, as they look at infant circumcision today, as something of little merit and only tolerated for consenting adults. - Kalle Pihlajasaari 2013 With just two ducks, they are always in a row. - Kalle Pihlajasaari 2013 Don't settle for the silver lining on your clouds, keep an eye out for the gold trim as well. - Kalle Pihlajasaari 2009